Although we cannot truly compare COVID-19 with HIV, there are similarities worth exploring. As the COVID-19 epidemiological data pours in, we have learned that communities of color are at heightened risk for hospitalization and death. With the reality that the economic fallout affects minority communities more than anyone else, it is clear the odds are against us yet again. We have seen this story play out throughout the course of the HIV epidemic, with LGBTQ, black and Latinx communities enduring the brunt of the disease’s burden. These health disparities are the result of structural inequities that our nation has not yet found the resolve to address. So, just as we did in the early days of HIV, we must arm ourselves with knowledge and a community-driven purpose to protect ourselves and those around us from COVID-19.