Clinicians. Administrators. Researchers. Procurement specialists. Regulators. Supply chain experts. Community-based workers. Donors. Advocates. Policymakers. These are just some of the roles required to implement effective, evidence-based global health and development initiatives. Yet many professionals are struggling with feelings of overwhelm, disconnection and exhaustion. In the past several years, we have lived and worked through a global pandemic, which exacerbated many pre–existing stressors. In this context, it is critical for us to address the risk of burnout among our staff and partners around the world.